Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor
- 1 June 1990
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 248 (4959), 1122-1124
- https://doi.org/10.1126/science.2111583
Abstract
The amyloid beta peptide (A beta P) is a small fragment of the much larger, broadly distributed amyloid precursor protein (APP). Abundant A beta P deposition in the brains of patients with Alzheimer's disease suggests that altered APP processing may represent a key pathogenic event. Direct protein structural analyses showed that constitutive processing in human embryonic kidney 293 cells cleaves APP in the interior of the A beta P, thus preventing A beta P deposition. A deficiency of this processing event may ultimately prove to be the etiological event in Alzheimer's disease that gives rise to senile plaque formation.Keywords
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