Role of intestinal microbiota and metabolites on gut homeostasis and human diseases
Top Cited Papers
Open Access
- 6 January 2017
- journal article
- review article
- Published by Springer Science and Business Media LLC in BMC Immunology
- Vol. 18 (1), 1-25
- https://doi.org/10.1186/s12865-016-0187-3
Abstract
A vast diversity of microbes colonizes in the human gastrointestinal tract, referred to intestinal microbiota. Microbiota and products thereof are indispensable for shaping the development and function of host innate immune system, thereby exerting multifaceted impacts in gut health. This paper reviews the effects on immunity of gut microbe-derived nucleic acids, and gut microbial metabolites, as well as the involvement of commensals in the gut homeostasis. We focus on the recent findings with an intention to illuminate the mechanisms by which the microbiota and products thereof are interacting with host immunity, as well as to scrutinize imbalanced gut microbiota (dysbiosis) which lead to autoimmune disorders including inflammatory bowel disease (IBD), Type 1 diabetes (T1D) and systemic immune syndromes such as rheumatoid arthritis (RA). In addition to their well-recognized benefits in the gut such as occupation of ecological niches and competition with pathogens, commensal bacteria have been shown to strengthen the gut barrier and to exert immunomodulatory actions within the gut and beyond. It has been realized that impaired intestinal microbiota not only contribute to gut diseases but also are inextricably linked to metabolic disorders and even brain dysfunction. A better understanding of the mutual interactions of the microbiota and host immune system, would shed light on our endeavors of disease prevention and broaden the path to our discovery of immune intervention targets for disease treatment.Keywords
Funding Information
- National Natural Science Foundation of China (CN) (81230034)
- National Natural Science Foundation of China (81371609)
- Natural Science Foundation of Jiangsu Province (CN) (BK20151133)
This publication has 152 references indexed in Scilit:
- Gut microbiota-derived propionate reduces cancer cell proliferation in the liverBritish Journal of Cancer, 2012
- The Genome of Th17 Cell-Inducing Segmented Filamentous Bacteria Reveals Extensive Auxotrophy and Adaptations to the Intestinal EnvironmentCell Host & Microbe, 2011
- Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatmentEMBO Molecular Medicine, 2011
- How Tolerogenic Dendritic Cells Induce Regulatory T CellsPublished by Elsevier BV ,2010
- Host–Bacterial Symbiosis in Health and DiseasePublished by Elsevier BV ,2010
- Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 CellsImmunity, 2010
- Pathogenesis of human systemic lupus erythematosus: recent advancesTrends in Molecular Medicine, 2010
- Induction of Intestinal Th17 Cells by Segmented Filamentous BacteriaCell, 2009
- Commensal DNA Limits Regulatory T Cell Conversion and Is a Natural Adjuvant of Intestinal Immune ResponsesImmunity, 2008
- An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune SystemCell, 2005