Cellular Heterogeneity in Adipose Tissues
- 10 February 2021
- journal article
- review article
- Published by Annual Reviews in Annual Review of Physiology
- Vol. 83 (1), 257-278
- https://doi.org/10.1146/annurev-physiol-031620-095446
Abstract
Adipose tissue depots in distinct anatomical locations mediate key aspects of metabolism, including energy storage, nutrient release, and thermogenesis. Although adipocytes make up more than 90% of adipose tissue volume, they represent less than 50% of its cellular content. Here, I review recent advances in genetic lineage tracing and transcriptomics that reveal the identities of the heterogeneous cell populations constituting mouse and human adipose tissues. In addition to mature adipocytes and their progenitors, these include endothelial and various immune cell types that together orchestrate adipose tissue development and functions. One salient finding is the identification of progenitor subtypes that can modulate adipogenic capacity through paracrine mechanisms. Another is the description of fate trajectories of monocyte/macrophages, which can respond maladaptively to nutritional and thermogenic stimuli, leading to metabolic disease. These studies have generated an extraordinary source of publicly available data that can be leveraged to explore commonalities and differences among experimental models, providing new insights into adipose tissues and their role in metabolic disease.Keywords
This publication has 98 references indexed in Scilit:
- The Vascular Endothelium of the Adipose Tissue Gives Rise to Both White and Brown Fat CellsCell Metabolism, 2012
- Tissular Tregs: A unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolismSeminars in Immunology, 2011
- The evolution of the adipose tissue: A neglected enigmaGeneral and Comparative Endocrinology, 2011
- Single-cell analysis of insulin-regulated fatty acid uptake in adipocytesAmerican Journal of Physiology-Endocrinology and Metabolism, 2010
- In vivo depletion of CD4+FOXP3+ Treg cells by the PC61 anti‐CD25 monoclonal antibody is mediated by FcγRIII+ phagocytesEuropean Journal of Immunology, 2010
- White Fat Progenitor Cells Reside in the Adipose VasculatureScience, 2008
- Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patternsAmerican Journal of Physiology-Endocrinology and Metabolism, 2007
- Multilineage Cells from Human Adipose Tissue: Implications for Cell-Based TherapiesTissue Engineering, 2001
- Morphological studies on the adrenergic innervation of white adipose tissueThe Anatomical Record, 1978
- The fine structure of brown adipose tissue: I. Cold-induced changes in the ratJournal of Ultrastructure Research, 1969