Stereotactic body radiation therapy for small primary or recurrent hepatocellular carcinoma in 132 Chinese patients
- 14 December 2015
- journal article
- research article
- Published by Wiley in Journal of Surgical Oncology
- Vol. 113 (2), 181-187
- https://doi.org/10.1002/jso.24128
Abstract
Aim To evaluate the efficacy of stereotactic body radiation therapy (SBRT) in small hepatocellular carcinoma (HCC) patients. Methods From March 2009 to April 2015, we treated 132 small HCC patients with SBRT. Eligibility criteria included longest tumor diameter ≤5.0 cm; Child‐Turcotte‐Pugh (CTP) Class A or B; unfeasible, difficult or refusal to undergo other surgery or percutaneous ablative therapies; and tumor recurrence after other local treatment. The dose of 42–46 Gy in 3–5 fractions and 28–30 Gy in 1 fraction was prescribed. Results Of the treated patients, 114 were classified as CTP A and 18 as CTP B. Median tumor size was range 1.1–5.0 cm. The local control rate at 1 years was 90.9%. OS at 1, 3, and 5 years was 94.1%, 73.5%, and 64.3%, respectively. PFS at 1, 3, and 5 years was 82.7%, 58.3%, and 36.4%, respectively. Hepatic toxicity grade ≥3 was observed in 11 patients. Multivariate analysis revealed that CTP B was associated with worse OS (P < 0.001) and multiple nodules were associated with worse PFS (P = 0.001). Conclusions SBRT is a promising alternative treatment for patients with primary or recurrent small HCC who are unsuitable for surgical resection or local ablative therapy. J. Surg. Oncol. 2016;113:181–187.This publication has 25 references indexed in Scilit:
- Stereotactic Body Radiation Therapy as an Alternative Treatment for Small Hepatocellular CarcinomaPLOS ONE, 2013
- Stereotactic body radiotherapy for small hepatocellular carcinoma: A retrospective outcome analysis in 185 patientsActa Oncologica, 2013
- Stereotactic body radiation therapy combined with transcatheter arterial chemoembolization for small hepatocellular carcinomaJournal of Gastroenterology and Hepatology, 2012
- Stereotactic Body Radiation Therapy in Recurrent Hepatocellular CarcinomaInternational Journal of Radiation Oncology*Biology*Physics, 2012
- A Randomized Trial Comparing Radiofrequency Ablation and Surgical Resection for HCC Conforming to the Milan CriteriaAnnals of Surgery, 2010
- Long-term effect of stereotactic body radiation therapy for primary hepatocellular carcinoma ineligible for local ablation therapy or surgical resection. Stereotactic radiotherapy for liver cancerBMC Cancer, 2010
- Preliminary result of stereotactic body radiotherapy as a local salvage treatment for inoperable hepatocellular carcinomaJournal of Surgical Oncology, 2010
- Modified RECIST (mRECIST) Assessment for Hepatocellular CarcinomaSeminars in Liver Disease, 2010
- Stereotactic body radiation therapy with or without transarterial chemoembolization for patients with primary hepatocellular carcinoma: preliminary analysisBMC Cancer, 2008
- HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS: A Prospective Study of 22 707 Men in TaiwanThe Lancet, 1981