Perhexiline neuropathy: A clinicopathological study
- 1 March 1978
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 3 (3), 259-266
- https://doi.org/10.1002/ana.410030313
Abstract
Five patients developed a mild to severe polyneuropathy while under treatment with perhexiline maleate, a drug used in long‐term treatment for angina pectoris. Recovery took place within a few months after drug withdrawal. We performed qualitative and quantitative light and electron microscopical studies, including teased fiber preparations, in different patients; 16 to 90% of the fibers showed segmental demyelination, an unusual feature in drug‐induced neuropathies, and 3 to 20% were undergoing wallerian degeneration. Severe loss of myelinated axons was noted in all 5 patients. In these patients clinical symptoms occurred only when a great number of fibers had already been lost and most of the surviving fibers showed demylination.Keywords
This publication has 4 references indexed in Scilit:
- PERIPHERAL-NERVE LIPID ABNORMALITIES IN PATIENTS ON PERHEXILINE MALEATEThe Lancet, 1977
- Etude en microscopie électronique des lésions nerveuses, musculaires et cutanées déterminées par le maléate de perhexilineActa Neuropathologica, 1977
- Polyneuropathy after perhexiline maleate therapy.BMJ, 1976
- THE INFLAMMATORY LESION IN IDIOPATHIC POLYNEURITISMedicine, 1969