Lasiodiplodia theobromae as a cause of keratomycoses
- 1 January 1976
- journal article
- case report
- Published by Oxford University Press (OUP) in Medical Mycology
- Vol. 14 (2), 155-170
- https://doi.org/10.1080/00362177685190231
Abstract
Four cases of human keratitis caused by the tropical fungus Lasiodiplodia theobromae have been encountered in Miami, Florida bringing to 8 the number of cases reported in the world literature. Two of the ulcers were mild. Three patients recovered without severe impairment of vision after topical polyene treatment, but 1 patient with a severe ulcer required therapeutic keratoplasty after 11 days of topical natamycin. Histopathology revealed fungus deep in the cornea, invading Descemet's membrane. L. theobromae appeared to have collagenase activity in vitro. Inoculation of L. theobromae into the corneas of rabbits produced progressive ulcers. The fungus was endemic in Miami on home grown and imported bananas. Polyene antimycotic antibiotics were fungicidal for L. theobromae in vitro. Thiabendazole was effectively fungistatic but varied in fungicidal effect. Clotrimazole and miconazole were only incompletely fungistatic. Of 7 strains of L. theobromae tested, 4 were relatively resistant to 5-fluorocytosine. En Miami, Florida, se han visto cuatro casos humanos de queratitis producidos por el hongo Lasiodiplodia theobromae, con lo cual son ya 8 los casos descritos en la bibliografía mundial. Dos de las úlceras producidas eran de tipo medio. Tres de los pacientes, tratados topicalmente con antibióticos polienos, se recuperaron sin grave trastorno en la visión, mientras que el otro, que padecía una úlcera grave, necesitó un tratamiento queratoplástico después de once días del empleo tópico de natamicina. Se observó el hongo en la córnea e invadiendo la membrana de Descemet. La inoculación de L. theobromae en la córnea de conejos, determinaba una ulceración progresiva. Se encontró que L. theobromae era endémica en plátanos del área de Miami, así como en importados. Antibióticos polienos antimicóticos, eran “in vitro” fungicidas contra L. theobromae. El tiabendazol era fuertemente fungistático, pero su poder fungicida era muy variable. El clotrimazol y miconazol eran sólo parcialmente fungistáticos. De las siete cepas de L. theobromae estudiadas, cuatro eran relativamenta resistentes a la 5-fluorocitosina.Keywords
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