Cardiac Transplantation: Where Are We?

Abstract

In this issue of the Journal, Bailey and his associates document successful short-term survival in three infants who underwent cardiac transplantation for hypoplastic left heart syndrome.¹ The authors are to be congratulated for accomplishing this in a group of patients who are difficult to care for postoperatively because of their size and the lack of access for repeated myocardial biopsies to detect allograft rejection. The occurrence of one or more episodes of rejection in all three infants despite immunosuppression with cyclosporine and azathioprine is disappointing, since it had been hoped that a less mature immune system might tolerate a . . .