Neuronal and microglial mechanisms of neuropathic pain
Open Access
- 1 January 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Molecular Brain
- Vol. 4 (1), 31
- https://doi.org/10.1186/1756-6606-4-31
Abstract
Neuropathic pain is generally defined as a chronic pain state resulting from peripheral and/or central nerve injury. Effective treatment for neuropathic pain is still lacking, due in part to poor understanding of pathological mechanisms at the molecular level. Neuronal mechanisms of neuropathic pain, especially synaptic plasticity, are the major focus of many investigators. N-methyl-D-aspartate (NMDA) receptor dependent synaptic plasticity at the spinal and cortical levels is believed to contribute to enhanced sensory responses after injury. Glial cells, including astrocytes and microglia, have recently been implicated in neuropathic pain. These glial cells form close interactions with neurons and thus may modulate nociceptive transmission under pathological conditions. In this review, we present recent progress in the study of neuronal and microglial mechanisms underlying neuropathic pain. We propose that activity-dependent neuronal plasticity is a key target for treatment in neuropathic pain.Keywords
This publication has 112 references indexed in Scilit:
- IFN-γ receptor signaling mediates spinal microglia activation driving neuropathic painProceedings of the National Academy of Sciences of the United States of America, 2009
- Pathological and protective roles of glia in chronic painNature Reviews Neuroscience, 2009
- Selective Activation of Microglia in Spinal Cord but Not Higher Cortical Regions Following Nerve Injury in Adult MouseMolecular Pain, 2008
- Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkineBrain, Behavior, and Immunity, 2007
- Inhibition of spinal microglial cathepsin S for the reversal of neuropathic painProceedings of the National Academy of Sciences of the United States of America, 2007
- UDP acting at P2Y6 receptors is a mediator of microglial phagocytosisNature, 2007
- Understanding LTP in Pain PathwaysMolecular Pain, 2007
- p38 MAPK, Microglial Signaling, and Neuropathic PainMolecular Pain, 2007
- Neuronal Mechanism for Neuropathic PainMolecular Pain, 2007
- Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic painNature, 2003