Abstract
Hay, S. (Dental Health Center, 14th Ave. and Lake St., San Francisco, Calif. 94118). Incidence of selected congenital malformations in Iowa. Amer J Epidem 94:572–584, 1971.—Congenital malformations diagnosed among 57, 909 live births and 777 late fetal deaths occurring in Iowa in 1963 were ascertained from hospital records, certificates of live birth, death and fetal death, and records of the State Crippled Children's Service. Anencephaly, spina bifida, hydrocephaly, cleft lip, cleft palate, congenital heart disease, Down's syndrome, hypospadias, congenital hip dislocation, reduction deformities, talipes equinovarus, and polydactyly were selected for special analysis. Except for central nervous system (CNS) anomalies and talipes, the incidence of these malformations tended to be high compared with other studies in which ascertainment was believed to be fairly complete. Sex ratios conformed to patterns previously reported. The incidence of some malformations was higher in births to women over 35 years of age than in births to younger women, whereas the opposite was observed for other malformations. For the majority of malformations under consideration more than one-third of the cases were associated with other anomalies. First year survival rates were lowest for those infants with CNS anomalies or cardiac defects and highest for those with polydactyly, hypospadias, and congenital hip dislocation.