Bone as a Possible Target of Chemical Toxicity of Natural Uranium in Drinking Water
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- 1 January 2005
- journal article
- Published by Environmental Health Perspectives in Environmental Health Perspectives
- Vol. 113 (1), 68-72
- https://doi.org/10.1289/ehp.7475
Abstract
Uranium accumulates in bone, affects bone metabolism in laboratory animals, and when ingested in drinking water increases urinary excretion of calcium and phosphate, important components in the bone structure. However, little is known about bone effects of ingested natural uranium in humans. We studied 146 men and 142 women 26–83 years of age who for an average of 13 years had used drinking water originating from wells drilled in bedrock, in areas with naturally high uranium content. Biochemical indicators of bone formation were serum osteocalcin and amino-terminal propeptide of type I procollagen, and a marker for bone resorption was serum type I collagen carboxy-terminal telopeptide (CTx). The primary measure of uranium exposure was uranium concentration in drinking water, with additional information on uranium intake and uranium concentration in urine. The data were analyzed separately for men and women with robust regression (which suppresses contributions of potential influential observations) models with adjustment for age, smoking, and estrogen use. The median uranium concentration in drinking water was 27 μg/L (interquartile range, 6–116 μg/L). The median of daily uranium intake was 36 μg (7–207 μg) and of cumulative intake 0.12 g (0.02–0.66 g). There was some suggestion that elevation of CTx (p = 0.05) as well as osteocalcin (p = 0.19) could be associated with increased uranium exposure (uranium in water and intakes) in men, but no similar relationship was found in women. Accordingly, bone may be a target of chemical toxicity of uranium in humans, and more detailed evaluation of bone effects of natural uranium is warranted.Keywords
This publication has 17 references indexed in Scilit:
- Osteoporosis and renal dysfunction in a general population exposed to cadmium in ChinaEnvironmental Research, 2004
- Assessment of bone metabolism in cadmium-induced renal tubular dysfunction by measurements of biochemical markersToxicology Letters, 2003
- Exposure to Subcutaneously Implanted Uranium Dioxide Impairs Bone FormationArchives of environmental health, 2002
- Chronic Ingestion of Uranium in Drinking Water: A Study of Kidney Bioeffects in HumansToxicological Sciences, 1998
- Chronic Ingestion of Uranium in Drinking Water: A Study of Kidney Bioeffects in HumansToxicological Sciences, 1998
- Basis for the ICRPʼs Age-specific Biokinetic Model for UraniumHealth Physics, 1994
- Uranium inhibits bone formation in physiologic alveolar bone modeling and remodelingEnvironmental Research, 1991
- Renal bone disease 1990: An unmet challenge for the nephrologistKidney International, 1990
- The association between renal dysfunction and osteopenia in environmental cadmium-exposed subjectsEnvironmental Research, 1990
- Effects of acute intoxication with uranyl nitrate on bone formationCellular and Molecular Life Sciences, 1984