EEG in Phenylketonuria
- 1 February 1981
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 38 (2), 122-126
- https://doi.org/10.1001/archneur.1981.00510020080013
Abstract
• To determine the importance of an abnormal EEG in phenylketonuria (PKU), we reviewed 137 EEGs from 48 patients with PKU. Patients were divided into three groups: group 1 (n = 14) had only normal EEGs, group 2 (n = 20) had only abnormal EEGs, and group 3 (n = 14) initially had normal EEGs that later became abnormal. The most common EEG abnormality was focal paroxysmal discharge. Patients in group 2 started treatment at a later age and had a greater frequency of seizures and mental retardation. Phenylalanine levels greater than 20 mg/dL were more often associated with abnormal EEGs. Older patients were more likely to have abnormal EEGs; 78% of the 41 patients who had EEGs at age 6 or older had abnormal records, whereas only 15% of the 26 patients who had EEGs before the age of 6 had abnormal records. Conventionally treated patients with classic PKU and normal EEGs in infancy may have abnormal EEGs when retested later even though they remain on a restricted diet. Although not usually associated with clinical deterioration, abnormal EEGs may unveil the presence of CNS dysfunction even when a child is in satisfactory clinical condition.This publication has 18 references indexed in Scilit:
- NEUROLOGICAL ABNORMALITIES IN PHENYLKETONURIAActa Neurologica Scandinavica, 2009
- Long Term Studies of Untreated Phenylketonuria I: Intelligence or Mental AbilityNeuropediatrics, 1978
- Long Term Studies of Untreated Phenylketonuria II: The Plasma Phenylalanine LevelNeuropediatrics, 1978
- Mental development of phenylketonuric children on or off diet after the age of sixPsychological Medicine, 1976
- Electroencephalographic Findings in Children With PhenylketonuriaArchives of Pediatrics & Adolescent Medicine, 1975
- Electroencephalographic abnormalities in phenylpyruvic oligophreniaNeurology, 1968
- A Clinical and Electroencephalographic Study of a Pair of Monozygotic Twins with PhenylketonuriaActa Paediatrica, 1962
- THE ASSOCIATION OF PHENYLKETONURIA WITH LEUCODYSTROPHYJournal of Neurology, Neurosurgery & Psychiatry, 1962
- Studies on PhenylketonuriaA.M.A. Archives of Neurology & Psychiatry, 1957
- The electroencephalogram in phenylpyruvic oligophreniaElectroencephalography and Clinical Neurophysiology, 1955