Effectiveness of non-steroidal anti-inflammatory drugs and epidural anaesthesia in reducing the pain and stress responses to a surgical husbandry procedure (mulesing) in sheep
- 1 January 2008
- journal article
- research article
- Published by CSIRO Publishing in Australian Journal of Experimental Agriculture
- Vol. 48 (7), 1034-1039
- https://doi.org/10.1071/ea08050
Abstract
In this study, we examined the potential of several widely used non-steroidal anti-inflammatory drugs (NSAIDs) and other analgesics to reduce pain and stress in sheep after surgery. Because mulesing involves a greater degree of tissue trauma than other surgical husbandry procedures such as castration or tail-docking, it provides a more rigorous and conservative test to identify potentially useful analgesic strategies in sheep. Merino lambs (5 weeks of age) were randomised into eight treatment groups: (1) carprofen; (2) flunixin; (3) ketoprofen; (4) buprenorphine; (5) xylazine; (6) lignocaine epidural; (7) saline control; (8) sham control. The NSAIDs were administered 1.5 h before mulesing, buprenorphine 0.75 h and xylazine and lignocaine 0.25 h before mulesing. Pain- and discomfort-related behaviours were recorded for 12 h after mulesing, and plasma cortisol concentrations were measured before mulesing and 0.5, 6, 12, 24 and 48 h after mulesing. The results indicated that no single analgesic treatment provided satisfactory analgesia during both the surgical mulesing procedure and the ensuing period of pain associated with the inflammatory phase. However, there were indications that two NSAIDs (carprofen and flunixin) showed good potential as analgesics during the inflammatory phase. A combination of short- and long-acting analgesics may be needed to provide more complete pain relief. In conclusion, the administration of some NSAIDs offers the potential for good analgesia in sheep for the inflammatory phase following the tissue trauma of surgical husbandry procedures. Other analgesic options need to be considered if the acute stress response to the procedure is to be reduced.Keywords
This publication has 24 references indexed in Scilit:
- The effect of a topical anaesthetic formulation, systemic flunixin and carprofen, singly or in combination, on cortisol and behavioural responses of Merino lambs to mulesingAustralian Veterinary Journal, 2007
- Non‐steroidal anti‐inflammatory analgesics: a review of current practiceJournal of Veterinary Emergency and Critical Care, 2002
- Anaesthesia in sheepIn Practice, 2000
- Enantiospecific pharmacokinetics and pharmacodynamics of ketoprofen in sheepJournal of Veterinary Pharmacology and Therapeutics, 1999
- Efficacy of intra‐muscular analgesics for acute pain in sheepAustralian Veterinary Journal, 1996
- The effects of opioid and α2 adrenergic blockade on non‐steroidal anti‐inflammatory drug analgesia in sheepJournal of Veterinary Pharmacology and Therapeutics, 1995
- Effect of flunixin meglumine on the thresholds to mechanical stimulation in healthy and lame sheepResearch in Veterinary Science, 1995
- Effects of non-steroidal anti-inflammatory drugs on the hyperalgesia to noxious mechanical stimulation induced by the application of a tourniquet to a forelimb of sheepResearch in Veterinary Science, 1994
- Further studies on the antinociceptive activity and respiratory effects of buprenorphine in sheepJournal of Veterinary Pharmacology and Therapeutics, 1991
- Anaesthesia in sheep and goatsIn Practice, 1991