A Linear Pentapeptide Is a Quorum-Sensing Factor Required for mazEF -Mediated Cell Death in Escherichia coli
- 26 October 2007
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 318 (5850), 652-655
- https://doi.org/10.1126/science.1147248
Abstract
mazEF is a toxin-antitoxin module located on many bacterial chromosomes, including those of pathogens. Here, we report that Escherichia coli mazEF -mediated cell death is a population phenomenon requiring a quorum-sensing molecule that we call the extracellular death factor (EDF). Structural analysis revealed that EDF is a linear pentapeptide, Asn-Asn-Trp-Asn-Asn. Each of the five amino acids of EDF is important for its activity.Keywords
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