Malignant Glomus Tumor: A Case Report and Review of the Literature
- 1 September 1997
- journal article
- case report
- Published by Ovid Technologies (Wolters Kluwer Health) in The American Journal of Surgical Pathology
- Vol. 21 (9), 1096-1103
- https://doi.org/10.1097/00000478-199709000-00015
Abstract
This report concerns a malignant glomus tumor, a rare soft tissue tumor that was examined immunohistochemically and ultrastructurally. It occurred in a 44-year-old male patient who had suffered from dull pain and stiffness in the right thigh for 10 months. Radiographic examination revealed a well-defined osteolytic lesion in the diaphysis of the right femur. Hypervascularity of the tumor was observed angiographically. Computed tomographic and magnetic resonance examinations showed an intramuscular mass invading the marrow space of the femur. Wide resection was performed after open biopsy. Histologically, round to polygonal tumor cells revealed a uniform appearance of round to ovoid nuclei with single large nucleoli and slightly eosinophilic cytoplasm, forming solid sheets of cells interrupted by vessels of varying size. A few mitotic figures and vascular invasion were observed. Immunohistochemically, vimentin and α-smooth muscle actin were stained intensely, and muscle actin was positive for tumor cells of the perivascular area. Tumor cells were negative for desmin, factor VIII-related antigen, S-100 protein, neurofilament, cytokeratin, and epithelial membrane antigen. Ultrastructurally, tumor cells were characterized by many cytoplasmic processes, pinocytotic vesicles, plasmalemmal dense plaques, and scattered microfilaments in the cytoplasm. Few cell junctions and focal basement membrane-like structures were observed. No recurrence or metastasis was noted 57 months after operation. This case was considered to be a malignant glomus tumor, that is, a glomangiosarcoma arising de novo.Keywords
This publication has 16 references indexed in Scilit:
- Malignant Glomus TumorThe American Journal of Surgical Pathology, 1996
- Case report 749Skeletal Radiology, 1992
- Multiple Glomus Tumors of the Stomach With Intravascular SpreadThe American Journal of Surgical Pathology, 1992
- Glomus tumours of the skin: an immunohistochemical investigation of the expression of marker proteinsBritish Journal of Dermatology, 1991
- Malignant glomus tumor originating in the superior mediastinum: an immunohistochemical and ultrastructural studyJournal of Korean Medical Science, 1991
- Glomus tumours: an immunohistochemical profile of 11 casesHistopathology, 1989
- Ultrastructural Spectrum of Hemangiopericytoma: A Comparative Study of Fetal, Adult, and Neoplastic PericytesUltrastructural Pathology, 1989
- Glomus tumor cells: Evaluation of smooth muscle and endothelial cell propertiesVirchows Archiv B Cell Pathology Including Molecular Pathology, 1983
- One very rare and one new tracheal tumour found by electron microscopy: glomus tumour and acinic cell tumour resembling carcinoid tumours by light microscopy.Thorax, 1982
- Infiltrating glomus tumour of lower limb.BMJ, 1972