CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors
- 1 November 1997
- journal article
- review article
- Published by Annual Reviews in Annual Review of Cell and Developmental Biology
- Vol. 13 (1), 261-291
- https://doi.org/10.1146/annurev.cellbio.13.1.261
Abstract
▪ Abstract Cyclin-dependent kinases (Cdks) play a well-established role in the regulation of the eukaryotic cell division cycle and have also been implicated in the control of gene transcription and other processes. Cdk activity is governed by a complex network of regulatory subunits and phosphorylation events whose precise effects on Cdk conformation have been revealed by recent crystallographic studies. In the cell, these regulatory mechanisms generate an interlinked series of Cdk oscillators that trigger the events of cell division.Keywords
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