Validated measurement of periarticular bone mineral density at the knee joint by dual energy x ray absorptiometry
Open Access
- 1 January 2001
- journal article
- research article
- Published by BMJ in Annals Of The Rheumatic Diseases
- Vol. 60 (1), 8-13
- https://doi.org/10.1136/ard.60.1.8
Abstract
OBJECTIVE The association of inflammatory arthritis with loss of periarticular bone mineral density (BMD) has been well established. However, changes in bone density cannot be quantified by conventional radiography. This study aimed at developing a new technique for measurement of periarticular bone density at the knee joint by dual energyx ray absorptiometry (DXA) and assessing the precision of this technique for selected areas around the knee. METHODS To validate this technique for bone density assessment in both patient and control subjects, knee joints from healthy subjects and patients with inflammatory arthritis were selected for study. Posteroanterior (PA) and lateral scans of both knees were acquired with the Hologic 4500 elite bone densitometer. Each scan was repeated three times, with repositioning between scans. Knee scans were obtained with the forearm software and evaluated by subregion analysis. Seven femoral and seven tibial subregions of interest (ROIs) were selected on PA scans. Six ROIs were selected on lateral scans. Precision was determined for each ROI selected. RESULTS 14 knee joints were studied in each group. Precision, expressed as percentage coefficient of variation (CV%), varied widely between subregions. PA scans were most appropriate for measurement of femoral bone density (CV% = 1.89–2.64%), whereas the best value obtained for ROIs within the tibia was on the lateral scan, where CV% for measurement of the proximal 5 mm was 2.67% in the patient group. CV% for BMD of the patella was excellent at 0.84% in the patient group. CONCLUSION This new application of DXA can be used to measure periarticular bone density at the knee joint. Regions within the distal femur and patella have been identified as the optimal areas to studyKeywords
This publication has 16 references indexed in Scilit:
- Clinical associations of dual-energy X-ray absorptiometry measurement of hand bone mass in rheumatoid arthritisRheumatology, 1996
- BONE MASS MEASUREMENT AND BONE METABOLISM IN RHEUMATOID ARTHRITIS: A REVIEWRheumatology, 1996
- Longitudinal study of hand bone densitometry in rheumatoid arthritisArthritis & Rheumatism, 1995
- Accurate assessment of precision errors: How to measure the reproducibility of bone densitometry techniquesOsteoporosis International, 1995
- Osteoporosis in rheumatoid arthritisArthritis & Rheumatism, 1995
- Measurement of hand bone mineral content by dual energy x-ray absorptiometry: development of the method, and its application in normal volunteers and in patients with rheumatoid arthritis.Annals Of The Rheumatic Diseases, 1994
- Bone mass in patients with rheumatoid arthritis.Annals Of The Rheumatic Diseases, 1992
- Measurement of hand bone mineral content using single-photon absorptiometryPhysics in Medicine & Biology, 1987
- Total and peripheral bone mass in patients with psoriatic arthritis and rheumatoid arthritisClinical Rheumatology, 1986
- Particle body neutron activation analysis in vivo: A new approach to the investigation of metabolic bone diseasePhysics in Medicine & Biology, 1973