Pathogenesis of Dengue: Challenges to Molecular Biology
- 29 January 1988
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 239 (4839), 476-481
- https://doi.org/10.1126/science.3277268
Abstract
Dengue viruses occur as four antigenically related but distinct serotypes transmitted to humans by Aedes aegypti mosquitoes. These viruses generally cause a benign syndrome, dengue fever, in the American and African tropics, and a severe syndrome, dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), in Southeast Asian children. This severe syndrome, which recently has also been identified in children infected with the virus in Puerto Rico, is characterized by increased vascular permeability and abnormal hemostasis. It occurs in infants less than 1 year of age born to dengue-immune mothers and in children 1 year and older who are immune to one serotype of dengue virus and are experiencing infection with a second serotype. Dengue viruses replicate in cells of mononuclear phagocyte lineage, and subneutralizing concentrations of dengue antibody enhance dengue virus infection in these cells. This antibody-dependent enhancement of infection regulates dengue disease in human beings, although disease severity may also be controlled genetically, possibly by permitting and restricting the growth of virus in monocytes. Monoclonal antibodies show heterogeneous distribution of antigenic epitopes on dengue viruses. These epitopes serve to regulate disease: when antibodies to shared antigens partially neutralize heterotypic virus, infection and disease are dampened; enhancing antibodies alone result in heightened disease response. Further knowledge of the structure of dengue genomes should permit rapid advances in understanding the pathogenetic mechanisms of dengue.Keywords
This publication has 81 references indexed in Scilit:
- Why dengue haemorrhagic fever in Cuba? I. Individual risk factors for dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS)Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987
- An electron and immunoelectron microscopic study of dengue-2 virus infection of cultured mosquito cells: Maturation eventsArchiv für die gesamte Virusforschung, 1987
- Study of the distribution of antibody‐ dependent enhancement determinants on dengue 2 isolates using dengue 2‐derived monoclonal antibodiesJournal of Medical Virology, 1987
- Partial sequence analysis of cloned dengue virus type 2 genomeGene, 1986
- Aedes aegypti mosquitoes in the Americas: A review of their interactions with the human populationSocial Science & Medicine (1982), 1986
- An outbreak of dengue virus at Rio de Janeiro - 1986Memórias do Instituto Oswaldo Cruz, 1986
- Partial nucleotide sequence of the Murray Valley encephalitis virus genome: Comparison of the encoded polypeptides with yellow fever virus structural and non-structural proteinsJournal of Molecular Biology, 1986
- Flavivirus Infection Enhancement in Macrophages: an Electron Microscopic Study of Viral Cellular EntryJournal of General Virology, 1985
- Cross‐protection and cross‐reactive cytotoxic T cells induced by influenza virus vaccines in miceEuropean Journal of Immunology, 1980
- Antibody-enhanced dengue virus infection in primate leukocytesNature, 1977