Exposure Levels of Environmental Endocrine Disruptors in Mother-Newborn Pairs in China and Their Placental Transfer Characteristics
Open Access
- 7 May 2013
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 8 (5), e62526
- https://doi.org/10.1371/journal.pone.0062526
Abstract
There is a growing concern about the potential health effects of exposure to various environmental chemicals during pregnancy and infancy. The placenta is expected to be an effective barrier protecting the developing embryo against some endocrine disruptors (EDs) circulating in maternal blood. The current study was designed to assess in utero exposure levels of non-persistent organic pollutants (non-POPs) and persistent organic pollutants (POPs) in Chinese newborns and potential role of placenta barrier against fetal exposure to these commonly-used environmental endocrine disruptors. A total of 230 newborn-mother pairs were enrolled during 2010–2011, 201 pairs of which were recruited from Shanghai, and the other 29 pairs came from Wenzhou. Maternal blood, cord blood, and meconium specimens were collected in the subject population from Shanghai and analyzed for non-POPs, including mono-2-ethylhexyl phthalate (MEHP), octylphenol (OP) and 4-nonylphenol (4-NP). A total of 19 polybrominated diphenyl ethers (PBDEs) congeners, which belong to POPs, were detected in maternal and cord blood specimens from the other 29 pairs. Fetal-maternal ratios (F-M ratios) and regression coefficients were presented to assess potential function of placenta on barricading the mother/fetal transfer of these EDs. Concentrations of the detected non-POPs in cord blood samples were approximately 20% lower than those in maternal blood, and regression coefficients of which were all over 0.80. In contrast, PBDEs levels in cord blood samples were significantly higher than those in maternal blood. MEHP levels in meconium were much higher than those in cord blood samples, and highly correlated. Therefore, observations demonstrated that the placental barrier slightly decreased the fetal exposure to most non-POPs, while PBDEs seemed to be totally transferred across the placenta and finally reached the fetus. For in utero exposure assessment of Di-2-ethylhexyl phthalate (DEHP), MEHP level in meconium may be a useful biomarker.Keywords
This publication has 40 references indexed in Scilit:
- Fetal and Neonatal Endocrine DisruptorsJournal of Clinical Research in Pediatric Endocrinology, 2012
- Polybromodiphenyl ethers in mothers and their newborns from a non-occupationally exposed population (Valencia, Spain)Environment International, 2011
- Prenatal Exposure to PBDEs and NeurodevelopmentEnvironmental Health Perspectives, 2010
- Polybrominated Diphenyl Ethers in Umbilical Cord Blood and Relevant Factors in Neonates from Guiyu, ChinaEnvironmental Science & Technology, 2009
- Distribution of phthalate esters in urban soils of subtropical city, Guangzhou, ChinaJournal of Hazardous Materials, 2009
- Phthalate Diesters and Their Metabolites in Human Breast Milk, Blood or Serum, and Urine as Biomarkers of Exposure in Vulnerable PopulationsEnvironmental Health Perspectives, 2008
- Quantifying Phthalate Metabolites in Human Meconium and Semen Using Automated Off-Line Solid-Phase Extraction Coupled with On-Line SPE and Isotope-Dilution High-Performance Liquid Chromatography−Tandem Mass SpectrometryAnalytical Chemistry, 2006
- Exposure to Low Concentrations of Di-n-butyl Phthalate During Embryogenesis Reduces Survivability and Impairs Development of Xenopus Laevis FrogsJournal of Toxicology and Environmental Health, Part A, 2005
- Analysis of selected pesticides and alkylphenols in human cord blood by gas chromatograph-mass spectrometerTalanta, 2003
- Atsdr Evaluation Of Health Effects Of Chemicals. Vi. Di(2-Ethylhexyl)Phthalate.Toxicology and Industrial Health, 1999