Advanced paternal age and reproductive outcome
Open Access
- 12 December 2011
- journal article
- review article
- Published by Medknow in Asian Journal of Andrology
- Vol. 14 (1), 69-76
- https://doi.org/10.1038/aja.2011.69
Abstract
Women have been increasingly delaying the start of motherhood in recent decades. The same trend is seen also for men. The influence of maternal age on fertility, chromosomal anomalies, pregnancy complications, and impaired perinatal and post-natal outcome of offspring, has been thoroughly investigated, and these aspects are clinically applied during fertility and pregestational counseling. Male aging and reproductive outcome has gained relatively less attention. The purpose of this review is to evaluate updated and relevant literature on the effect of paternal age on reproductive outcome.Keywords
This publication has 107 references indexed in Scilit:
- Paternal age and psychiatric disorders: Findings from a Dutch population registrySchizophrenia Research, 2011
- Paternal age related schizophrenia (PARS): Latent subgroups detected by k-means clustering analysisSchizophrenia Research, 2011
- Epigenetics and the origins of paternal effectsHormones and Behavior, 2011
- Association of Paternal Age and Risk for Major Congenital Anomalies From the National Birth Defects Prevention Study, 1997 to 2004Annals of Epidemiology, 2010
- Meta-analysis of Paternal Age and Schizophrenia Risk in Male Versus Female OffspringSchizophrenia Bulletin, 2010
- Large-scale parent–child comparison confirms a strong paternal influence on telomere lengthEuropean Journal of Human Genetics, 2009
- Telomere biology in healthy aging and diseasePflügers Archiv - European Journal of Physiology, 2009
- A germ-line-selective advantage rather than an increased mutation rate can explain some unexpectedly common human disease mutationsProceedings of the National Academy of Sciences of the United States of America, 2008
- Telomere length is paternally inherited and is associated with parental lifespanProceedings of the National Academy of Sciences of the United States of America, 2007
- Advancing age has differential effects on DNA damage, chromatin integrity, gene mutations, and aneuploidies in spermProceedings of the National Academy of Sciences of the United States of America, 2006