The Effect of Oral Sucrose on Exercise Tolerance in Patients with McArdle's Disease
- 25 December 2003
- journal article
- clinical trial
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 349 (26), 2503-2509
- https://doi.org/10.1056/nejmoa031836
Abstract
Energy metabolism in muscles relies predominantly on the breakdown of glycogen early in exercise. In patients with McArdle's disease, blocked glycogenolysis in muscles results in low exercise tolerance and can lead to muscle injury, particularly in the first minutes of exercise. We hypothesized that ingesting sucrose before exercise would increase the availability of glucose and would therefore improve exercise tolerance in patients with McArdle's disease.Keywords
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