Chronic complications of venous thromboembolism
- 1 August 2017
- journal article
- review article
- Published by Wiley in Journal of Thrombosis and Haemostasis
- Vol. 15 (8), 1531-1540
- https://doi.org/10.1111/jth.13741
Abstract
Summary Venous thromboembolism (VTE) is a common disease (~700 per 100 000) that is associated with significant risk of recurrence, chronic complications, and substantial mortality, with reported death rates of up to 40% at 10 years. The development of novel anticoagulants has revolutionized the treatment of acute VTE, while strategies for prevention and treatment of chronic complications still seek for such a landmark change. Impaired thrombus resolution is the common denominator behind VTE complications, which are postthrombotic syndrome (PTS) and chronic thromboembolic pulmonary hypertension (CTEPH). PTS and CTEPH are associated with substantial morbidity and high healthcare expenses. While PTS occurs in up to 50% of patients after symptomatic deep vein thrombosis, only a small and poorly defined number of patients are diagnosed with CTEPH after pulmonary embolism. This review is a comprehensive summary of VTE‐related chronic complications, their epidemiology, diagnosis, and treatment.Keywords
Funding Information
- Austrian Science Fund
This publication has 94 references indexed in Scilit:
- Chronic post-embolic pulmonary hypertension: a new target for medical therapies?European Respiratory Review, 2013
- Oral Apixaban for the Treatment of Acute Venous ThromboembolismNew England Journal of Medicine, 2013
- Percutaneous Transluminal Pulmonary Angioplasty for the Treatment of Chronic Thromboembolic Pulmonary HypertensionCirculation: Cardiovascular Interventions, 2012
- Refined Balloon Pulmonary Angioplasty for Inoperable Patients with Chronic Thromboembolic Pulmonary HypertensionCirculation: Cardiovascular Interventions, 2012
- Oral Rivaroxaban for the Treatment of Symptomatic Pulmonary EmbolismNew England Journal of Medicine, 2012
- Critical Review of Mouse Models of Venous ThrombosisArteriosclerosis, Thrombosis, and Vascular Biology, 2012
- Postthrombotic Syndrome: Surgical PossibilitiesThrombosis, 2011
- The Epidemiology of Venous Thromboembolism in the CommunityArteriosclerosis, Thrombosis, and Vascular Biology, 2008
- Economic burden of deep-vein thrombosis, pulmonary embolism, and post-thrombotic syndromeAmerican Journal of Health-System Pharmacy, 2006
- Prophylaxis of postoperative leg vine thrombosis by low dose subcutaneous heparin or peroperative calf muscle stimulation: a controlled clinical trial.BMJ, 1975