Insulin resistance, insulin‐like growth factor I and breast cancer: A hypothesis
- 9 August 1995
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 62 (4), 403-406
- https://doi.org/10.1002/ijc.2910620408
Abstract
Consideration of existing data regarding clinical and biochemical risk factors for the development of breast cancer leads to the hypothesis that enhanced insulin-like growth factor 1 (IGF-1) activity plays a significant role in the development of this disease. Abnormal IGF-1 activity may be related to events occurring prenatally, during puberty, or during adult life. Insulin resistance, a common feature in populations characterized by high caloric intake, may result in the amplification of IGF-1 action at the tissue level by altering serum concentrations of IGF-1 binding proteins. Several approaches toward testing the hypothesis are proposed, and potential opportunities for clinical application are described.Keywords
This publication has 54 references indexed in Scilit:
- Physical Exercise and Reduced Risk of Breast Cancer in Young WomenJNCI Journal of the National Cancer Institute, 1994
- Ethanol and breast cancer: An association that may be both confounded and causalInternational Journal of Cancer, 1994
- Plasma insulin-like growth factor-1 (IGF-1) concentrations in human breast cancerEuropean Journal Of Cancer, 1993
- Recombinant insulin‐like growth factor binding protein‐1 inhibits IGF‐I, serum, and estrogen‐dependent growth of MCF‐7 human breast cancer cellsJournal of Cellular Physiology, 1993
- Serum insulin-like growth factor-binding protein-2 (IGFBP-2) is increased and IGFBP-3 is decreased in patients with prostate cancer: correlation with serum prostate-specific antigenJournal of Clinical Endocrinology & Metabolism, 1993
- Regulation of Insulin-Like Growth Factor-Binding Protein (IGFBP) Expression by Breast Cancer Cells: Use of IGFBP-1 as as Inhibitor of Insulin-like Growth Factor ActionJNCI Journal of the National Cancer Institute, 1992
- Insulin regulation of insulin-like growth factor binding protein-1 in obese and nonobese humansJournal of Clinical Endocrinology & Metabolism, 1992
- The etiology of polycystic ovary syndrome (PCO)Medical Hypotheses, 1989
- Letter to the editorInternational Journal of Cancer, 1989
- Breast cancer and body buildPreventive Medicine, 1977