Cytokine gene polymorphisms and sudden infant death syndrome
- 1 February 2010
- journal article
- Published by Wiley in Acta Paediatrica
- Vol. 99 (3), 384-388
- https://doi.org/10.1111/j.1651-2227.2009.01611.x
Abstract
Aim: Several studies indicate that the mucosal immune system is stimulated in cases of sudden infant death syndrome (SIDS), and our hypothesis is that this immune reaction is because of an unfavourable combination of functional polymorphisms in the cytokine genes. Methods: Thus, in this study, single nucleotide polymorphisms (SNPs) in the genes encoding IL-6, IL-8, IL-12, IL-13, IL-16, IL-18 and IFNγ were investigated in 148 SIDS cases, 56 borderline SIDS cases, 41 cases of infectious death and 131 controls. Results: Regarding genotype distribution, no differences between the investigated groups were found. However, in the SIDS group, the genotypes IL-8 −251AA/AT and IL-8 −781CT/TT were significantly more frequent in the SIDS cases found dead in a prone sleeping position, compared with SIDS cases found dead in other sleeping positions. In addition, there was an association between fever prior to death and the genotype IL-13 +4464GG in the cases of infectious death. Conclusion: This study indicates that specific interleukin genotypes are a part of a genetic make up that make infants sleeping prone at risk for SIDS.Keywords
This publication has 27 references indexed in Scilit:
- Interleukin-6 and the serotonergic system of the medulla oblongata in the sudden infant death syndromeActa Neuropathologica, 2009
- Infection and sudden unexpected death in infancy: a systematic retrospective case reviewThe Lancet, 2008
- Sudden infant death syndrome, infection and inflammatory responsesFEMS Immunology & Medical Microbiology, 2004
- Interleukin 1-? responses to bacterial toxins and sudden infant death syndromeFEMS Immunology & Medical Microbiology, 2004
- Sudden Infant Death Syndrome and Unclassified Sudden Infant Deaths: A Definitional and Diagnostic ApproachPublished by American Academy of Pediatrics (AAP) ,2004
- Il-10 gene polymorphisms are associated with infectious cause of sudden infant deathHuman Immunology, 2003
- Association of IL-10 genotype with sudden infant death syndromeHuman Immunology, 2000
- IL-6 Cerebrospinal Fluid Levels Are Related to Laryngeal IgA and Epithelial HLA-DR Response in Sudden Infant Death SyndromePediatric Research, 1999
- S cases have increased levels of interleukin‐6 in cerebrospinal fluidActa Paediatrica, 1995
- Biochemical and immunological studies in SIDS victims. Clues to understanding the death mechanismActa Paediatrica, 1993