BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway
Open Access
- 30 April 2012
- journal article
- Published by Springer Science and Business Media LLC in BMC Biology
- Vol. 10 (1), 37
- https://doi.org/10.1186/1741-7007-10-37
Abstract
Efficient osteogenic differentiation is highly dependent on coordinated signals arising from growth factor signalling and mechanical forces. Bone morphogenetic proteins (BMPs) are secreted proteins that trigger Smad and non-Smad pathways and thereby influence transcriptional and non-transcriptional differentiation cues. Crosstalk at multiple levels allows for promotion or attenuation of signalling intensity and specificity. Similar to BMPs, mechanical stimulation enhances bone formation. However, the molecular mechanism by which mechanical forces crosstalk to biochemical signals is still unclear.Keywords
This publication has 71 references indexed in Scilit:
- More than a feeling: discovering, understanding, and influencing mechanosensing pathwaysCurrent Opinion in Biotechnology, 2011
- Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticityProceedings of the National Academy of Sciences of the United States of America, 2011
- Identification of a Key Residue Mediating Bone Morphogenetic Protein (BMP)-6 Resistance to Noggin Inhibition Allows for Engineered BMPs with Superior Agonist ActivityJournal of Biological Chemistry, 2010
- Integrin–TGF‐β crosstalk in fibrosis, cancer and wound healingEMBO Reports, 2010
- Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β PathwaysCell, 2009
- Boning up on Wolff's Law: Mechanical regulation of the cells that make and maintain boneJournal of Biomechanics, 2009
- Compressive forces induce osteogenic gene expression in calvarial osteoblastsJournal of Biomechanics, 2008
- Mechanical Load and BMP Signaling During Tendon Repair: A Role for Follistatin?Clinical Orthopaedics & Related Research, 2008
- Tumor cell cycle arrest induced by shear stress: Roles of integrins and SmadProceedings of the National Academy of Sciences of the United States of America, 2008
- Integrating Patterning Signals: Wnt/GSK3 Regulates the Duration of the BMP/Smad1 SignalCell, 2007