Gene-environment interaction and obesity
Open Access
- 19 November 2008
- journal article
- review article
- Published by Oxford University Press (OUP) in Nutrition Reviews
- Vol. 66 (12), 684-694
- https://doi.org/10.1111/j.1753-4887.2008.00128.x
Abstract
The epidemic of obesity has become a major public health problem. Common-form obesity is underpinned by both environmental and genetic factors. Epidemiological studies have documented that increased intakes of energy and reduced consumption of high-fiber foods, as well as sedentary lifestyle, were among the major driving forces for the epidemic of obesity. Recent genome-wide association studies have identified several genes convincingly related to obesity risk, including the fat mass and obesity associated gene and the melanocortin-4 receptor gene. Testing gene-environment interaction is a relatively new field. This article reviews recent advances in identifying the genetic and environmental risk factors (lifestyle and diet) for obesity. The evidence for gene-environment interaction, especially from observational studies and randomized intervention trials, is examined specifically. Knowledge about the interplay between genetic and environmental components may facilitate the choice of more effective and specific measures for obesity prevention based on the personalized genetic make-up.Keywords
This publication has 92 references indexed in Scilit:
- Fat Mass–and Obesity-Associated (FTO) Gene Variant Is Associated With ObesityDiabetes, 2008
- FTO Variants Are Associated With Obesity in the Chinese and Malay Populations in SingaporeDiabetes, 2008
- Common variants near MC4R are associated with fat mass, weight and risk of obesityNature Genetics, 2008
- Genome-Wide Association Scan Shows Genetic Variants in the FTO Gene Are Associated with Obesity-Related TraitsPLoS Genetics, 2007
- Variation in FTO contributes to childhood obesity and severe adult obesityNature Genetics, 2007
- A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult ObesityScience, 2007
- The Association of a SNP Upstream of INSIG2 with Body Mass Index is Reproduced in Several but Not All CohortsPLoS Genetics, 2007
- Genes, environment and the value of prospective cohort studiesNature Reviews Genetics, 2006
- Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common diseaseNature Genetics, 2003
- The Body-Mass Index of Twins Who Have Been Reared ApartThe New England Journal of Medicine, 1990