Vessel Growth and Function: Depiction with Contrast-enhanced MR Imaging
- 1 May 2009
- journal article
- review article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 251 (2), 317-335
- https://doi.org/10.1148/radiol.2512080485
Abstract
Magnetic resonance (MR) imaging is a versatile noninvasive diagnostic tool that can be applied to the entire human body to revealing morphologic, functional, and metabolic information. The authors review how MR imaging can depict both the established and the developing vasculature with techniques involving intravenously administered contrast agents. In addition to macrovascular morphology and flow, MR imaging is able to exploit microvascular properties, including vessel size distribution, hyperpermeability, flow heterogeneity, and possibly also upregulation of endothelial biomarkers. For each MR method, the basic principles, potential acquisition and interpretation pitfalls, solutions, and applications are described. Furthermore, discussion includes current shortcomings and the impact of future developments (eg, higher magnetic field strength systems, targeted macromolecular contrast agents) on the visualization of blood vessel growth and function with contrast-enhanced MR imaging.Keywords
This publication has 119 references indexed in Scilit:
- Collaterals: how important are they?Heart, 2007
- MRI Evaluation of the Contralateral Breast in Women with Recently Diagnosed Breast CancerNew England Journal of Medicine, 2007
- The delay of contrast arrival in magnetic resonance first-pass perfusion imaging: a novel non-invasive parameter detecting collateral-dependent myocardiumHeart, 2007
- Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sproutingProceedings of the National Academy of Sciences, 2007
- Inflammation in Carotid Atherosclerotic Plaque: A Dynamic Contrast-enhanced MR Imaging StudyRadiology, 2006
- Experimentally‐derived functional form for a population‐averaged high‐temporal‐resolution arterial input function for dynamic contrast‐enhanced MRIMagnetic Resonance in Medicine, 2006
- Angiogenesis in life, disease and medicineNature, 2005
- Relaxivity of liposomal paramagnetic MRI contrast agentsMagnetic Resonance Materials in Physics, Biology and Medicine, 2005
- Structural, Functional, and Molecular MR Imaging of the MicrovasculatureAnnual Review of Biomedical Engineering, 2003
- Magnetic resonance contrast enhancement of neovasculature with ?v?3-targeted nanoparticlesMagnetic Resonance in Medicine, 2000