Arterial hypoxemia and intrapulmonary vasodilatation in rat models of portal hypertension
- 2 September 2005
- journal article
- research article
- Published by Springer Science and Business Media LLC in The Esophagus
- Vol. 40 (8), 811-819
- https://doi.org/10.1007/s00535-005-1633-9
Abstract
Rats with chronic bile duct ligation (CBDL) and portal vein ligation (PVL) are used as models of portal hypertension. CBDL rats show hypoxemia with intrapulmonary vasodilatation (IPVD), and are recognized as a model of hepatopulmonary syndrome (HPS), while PVL rats are normoxemic. We investigated the differences in arterial oxygenation between these models, and the key factors leading to HPS.Keywords
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