Early control of HIV replication in primary HIV-1 infection treated with antiretroviral drugs and pegylated IFNα: results from the Primoferon A (ANRS 086) Study
- 1 July 2001
- journal article
- clinical trial
- Published by Ovid Technologies (Wolters Kluwer Health) in AIDS
- Vol. 15 (11), 1435-1437
- https://doi.org/10.1097/00002030-200107270-00014
Abstract
IFN alpha has both antiviral and immunostimulating properties. The ANRS086 Primoferon A Study evaluated in 12 patients with primary HIV infection the tolerance and efficacy of an early and transient administration of pegylated IFN alpha, in addition to highly active antiretroviral therapy. Tolerance was good, and this regimen allowed the early control of HIV replication and rapid decay of the viral reservoir. These results support the initiation of comparative studies with pegylated INF alpha in primary HIV infection.Keywords
This publication has 20 references indexed in Scilit:
- Proviral HIV-1 DNA in subjects followed since primary HIV-1 infection who suppress plasma viral load after one year of highly active antiretroviral therapyAIDS, 2001
- HIV RNA and HIV DNA in Peripheral Blood Mononuclear Cells Are Consistent Markers for Estimating Viral Load in Patients Undergoing Long-Term Potent TreatmentAIDS Research and Human Retroviruses, 2000
- Cell-associated HIV-1-DNA quantitation after highly active antiretroviral therapy-treated primary infection in patients with persistently undetectable plasma HIV-1 RNAAIDS, 2000
- Virological and Immunological Effects of Combination Antiretroviral Therapy with Zidovudine, Lamivudine, and Indinavir during Primary Human Immunodeficiency Virus Type 1 InfectionThe Journal of Infectious Diseases, 2000
- Highly Active Antiretroviral Treatment Initiated Early in the Course of Symptomatic Primary HIV‐1 Infection: Results of the ANRS 053 TrialThe Journal of Infectious Diseases, 1999
- Potent Antiretroviral Therapy of Primary Human Immunodeficiency Virus Type 1 (HIV‐1) Infection: Partial Normalization of T Lymphocyte Subsets and Limited Reduction of HIV‐1 DNA Despite Clearance of Plasma ViremiaThe Journal of Infectious Diseases, 1999
- Viral load and burden modification following early antiretroviral therapy of primary HIV-1 infectionAIDS, 1999
- Detection of Low HIV-1 RNA Levels in PlasmaJAIDS Journal of Acquired Immune Deficiency Syndromes, 1997
- Molecular Cloning of a New Interferon-induced Factor That Represses Human Immunodeficiency Virus Type 1 Long Terminal Repeat ExpressionPublished by Elsevier BV ,1995
- Inhibition by interferon of herpes simplex virus type 1-activated transcription of tat-defective provirus.Proceedings of the National Academy of Sciences of the United States of America, 1991