Biocorrosion properties and blood and cell compatibility of pure iron as a biodegradable biomaterial
- 16 April 2010
- journal article
- Published by Springer Science and Business Media LLC in Journal of Materials Science: Materials in Medicine
- Vol. 21 (7), 2151-2163
- https://doi.org/10.1007/s10856-010-4070-0
Abstract
Biocorrosion properties and blood- and cell compatibility of pure iron were studied in comparison with 316L stainless steel and Mg–Mn–Zn magnesium alloy to reveal the possibility of pure iron as a biodegradable biomaterial. Both electrochemical and weight loss tests showed that pure iron showed a relatively high corrosion rate at the first several days and then decreased to a low level during the following immersion due to the formation of phosphates on the surface. However, the corrosion of pure iron did not cause significant increase in pH value to the solution. In comparison with 316L and Mg–Mn–Zn alloy, the pure iron exhibited biodegradable property in a moderate corrosion rate. Pure iron possessed similar dynamic blood clotting time, prothrombin time and plasma recalcification time to 316L and Mg–Mn–Zn alloy, but a lower hemolysis ratio and a significant lower number density of adhered platelets. MTT results revealed that the extract except the one with 25% 24 h extract actually displayed toxicity to cells and the toxicity increased with the increasing of the iron ion concentration and the incubation time. It was thought there should be an iron ion concentration threshold in the effect of iron ion on the cell toxicity.This publication has 53 references indexed in Scilit:
- Contact activation of blood-plasma coagulationBiomaterials, 2009
- Small molecule inhibitors of divalent metal transporter-1American Journal of Physiology-Gastrointestinal and Liver Physiology, 2009
- In vitro corrosion and biocompatibility of binary magnesium alloysBiomaterials, 2009
- Thrombosis modeling in intracranial aneurysms: a lattice Boltzmann numerical algorithmComputer Physics Communications, 2008
- Myocyte Damage and Loss of Myofibers is the Potential Mechanism of Iron Overload Toxicity in Congestive Cardiac Failure in Thalassemia. Complete Reversal of the Cardiomyopathy and Normalization of Iron Load by DeferiproneHemoglobin, 2008
- Short‐Term Effects of Biocorrodible Iron Stents in Porcine Coronary ArteriesJournal of Interventional Cardiology, 2007
- Mechanisms of iron loading and toxicityAmerican Journal of Hematology, 2007
- Iron down-regulates macrophage anti-tumour activity by blocking nitric oxide productionClinical and Experimental Immunology, 2004
- Third-Generation Biomedical MaterialsScience, 2002
- Surface-Active BiomaterialsScience, 1984