Effect of Oral Insulin on Prevention of Diabetes in Relatives of Patients With Type 1 Diabetes

Abstract

In the Diabetes Prevention Trial–Type 1 (DPT-1),^1,2 oral insulin compared with placebo did not show a reduction in the development of diabetes, but a post hoc analysis identified an at-risk subgroup with higher insulin autoantibody titers that suggested benefit.² Consequently, the Type 1 Diabetes TrialNet clinical trials network, which succeeded the DPT-1 trial group, sought to further explore the role of oral insulin in delaying diabetes among relatives who were not significantly different from those in the subgroup who had experienced apparent benefit from oral insulin in DPT-1.