Ebselen Prevents Chronic Alcohol‐Induced Rat Hippocampal Stress and Functional Impairment
- 5 February 2007
- journal article
- Published by Wiley in Alcohol: Clinical and Experimental Research
- Vol. 31 (3), 486-492
- https://doi.org/10.1111/j.1530-0277.2006.00329.x
Abstract
Background: Most of the previously published data suggest a role for oxidative or nitrosative stress in ethanol‐induced nervous system damage. Moreover, ethanol is able to impair learning abilities in adult mammalian brain, a process suggested to be directly related to hippocampal neurogenesis. Ebselen, a synthetic compound with antioxidant properties, is able to prevent ethanol‐induced impairment of neurogenesis in adult rats. The aim of the present work was to further demonstrate the ability of ebselen to prevent biochemical alterations, and preserve long‐term potentiation (LTP) and learning abilities, in the hippocampus of chronic alcoholic adult rats. Methods: Biochemical markers of oxidative stress (glutathione and malondialdehyde) were assayed in hippocampi of control rats and animals fed a liquid alcoholic diet (Lieber‐De Carli) supplemented or not with ebselen. Long‐term potentiation and hippocampal‐dependent tests were studied in all animal groups. Results: The hippocampal concentrations of glutathione and malondialdehyde were decreased and increased, respectively, in alcohol‐treated animals, and did not differ from those of the control and the alcohol+ebselen groups. Long‐term potentiation in hippocampal slices from ethanol‐treated animals was prevented, when compared with controls, and occurred with a similar profile in control animals and in the alcohol+ebselen groups. Learning ability was tested with the Morris water maze test. Escape latencies were higher in ethanol‐treated rats than in control animals or the ones treated with ethanol+ebselen. Conclusions: The results herein strongly suggest that oxidative mechanisms may underlie the hippocampal effects of ethanol in adult rats, in view of the protective effect of ebselen.This publication has 72 references indexed in Scilit:
- Molecular Mechanisms Contributing to Long-Lasting Synaptic Plasticity at the Temporoammonic–CA1 SynapseLearning & Memory, 2003
- Impaired spatial and sequential learning in rats treated neonatally with d‐fenfluramineEuropean Journal of Neuroscience, 2002
- Efficacy of the antioxidant ebselen in experimental uveitisFree Radical Biology & Medicine, 1999
- NMDA receptor-dependent nitric oxide and cGMP synthesis in brain hemispheres and cerebellum during reperfusion after transient forebrain ischemia in gerbils: Effect of 7-nitroindazoleJournal of Neuroscience Research, 1998
- Nuclear DNA strand breaks during ethanol‐induced oxidative stress in rat brainFEBS Letters, 1996
- An alternative to the LTP orthodoxy: a plasticity-pathology continuum modelBrain Research Reviews, 1996
- Common Forms of Synaptic Plasticity in the Hippocampus and Neocortex in VitroScience, 1993
- Cortical and diencephalic lesions in Korsakoff's syndrome: a clinical and scan studyPsychological Medicine, 1990
- Selective hippocampal lesions and behavior: Effects of kainic acid lesions on performance of place and cue tasks.Behavioral Neuroscience, 1983
- Effects of Prolonged Ethanol Intake: Production of Fatty Liver Despite Adequate Diets*JCI Insight, 1965