Prognosis in Postural (Orthostatic) Proteinuria

Abstract

THE excellent prognosis traditionally offered to patients with postural (orthostatic) proteinuria has come under some suspicion in recent years; it has been stated that "large numbers of carefully studied patients will have to be followed over long periods of time before the natural history of postural and intermittent proteinuria can be finally elucidated."¹ To study this question, we reevaluated six patients in whom the diagnosis was made by Thomas Addis 42 to 50 years ago. Three had died of nonrenal causes (pulmonary carcinoma, myocardial infarction, and trauma) 42, 45, and 50 years after diagnosis; no renal disease was ever detected . . .