DNA Damage in Major Psychiatric Diseases
- 28 April 2016
- journal article
- review article
- Published by Springer Science and Business Media LLC in Neurotoxicity Research
- Vol. 30 (2), 251-267
- https://doi.org/10.1007/s12640-016-9621-9
Abstract
Human cells are exposed to exogenous insults and continuous production of different metabolites. These insults and unwanted metabolic products might interfere with the stability of genomic DNA. Recently, many studies have demonstrated that different psychiatric disorders show substantially high levels of oxidative DNA damage in the brain accompanied with morphological and functional alterations. It reveals that damaged genomic DNA may contribute to the pathophysiology of these mental illnesses. In this article, we review the roles of oxidative damage and reduced antioxidant ability in some vastly studied psychiatric disorders and emphasize the inclusion of treatment options involving DNA repair. In addition, while most currently used antidepressants are based on the manipulation of the neurotransmitter regulation in managing different mental abnormalities, they are able to prevent or reverse neurotoxin-induced DNA damage. Therefore, it may be plausible to target on genomic DNA alterations for psychiatric therapies, which is of pivotal importance for future antipsychiatric drug development.Keywords
Funding Information
- National Institute of Mental Health (MH080323)
This publication has 168 references indexed in Scilit:
- Life stress and kindling in bipolar disorder: Review of the evidence and integration with emerging biopsychosocial theoriesClinical Psychology Review, 2011
- A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro)degenerative processes in that illnessProgress in Neuro-Psychopharmacology and Biological Psychiatry, 2011
- Oxidative stress in schizophrenia: An integrated approachNeuroscience & Biobehavioral Reviews, 2011
- 8-Oxo-7,8-dihydroguanine: Links to gene expression, aging, and defense against oxidative stressFree Radical Biology & Medicine, 2010
- Free radicals and antioxidants in normal physiological functions and human diseaseThe International Journal of Biochemistry & Cell Biology, 2007
- DNA fragmentation is increased in non-GABAergic neurons in bipolar disorder but not in schizophreniaSchizophrenia Research, 2007
- DNA damage responses in neural cells: Focus on the telomereNeuroscience, 2007
- Iron, brain ageing and neurodegenerative disordersNature Reviews Neuroscience, 2004
- Diversity of structures and properties among catalasesCellular and Molecular Life Sciences, 2004
- The Corticosteroid Receptor Hypothesis of DepressionNeuropsychopharmacology, 2000