Recent Progress of Vascular Graft Engineering in Japan
- 9 January 2004
- journal article
- review article
- Published by Wiley in Artificial Organs
- Vol. 28 (1), 64-71
- https://doi.org/10.1111/j.1525-1594.2004.07324.x
Abstract
The development of a small‐diameter vascular graft has long been awaited. This review covers research activities, achievements and progress on vascular engineering in Japan, which was conducted over the last decade. The article includes recently developed experimental scaffolds, biologically active artificial extracellular matrices (ECMs) or non‐fouling synthetic coatings, cell sourcing including the autologous vascular cell type, endothelial progenitor cells and genetically‐engineered, temporary endothelial‐like cells. The discussions were presented from biomechanical, biomaterial, cellular and tissue aspects. Once the mechano‐biological and biologically active extracellular milieus are established in a designed vascular graft, the functional, structural and mechanical tissue morphogenesis and adaptation of implanted vascular grafts may proceed with implantation duration, and the spatio‐temporal tissue modulations at cytokine, cellular, ECM levels under physiological stress proceed to regenerate vascular tissue architecture. The ultimate solution to a small‐diameter vascular graft should be realized by optimal combinations of these factors.Keywords
This publication has 51 references indexed in Scilit:
- Intralumenal Tissue-Engineered Therapeutic Stent Using Endothelial Progenitor Cell-Inoculated Hybrid Tissue andin VitroPerformanceTissue Engineering, 2003
- Creation Of Viable Pulmonary Artery Autografts Through Tissue EngineeringThe Journal of Thoracic and Cardiovascular Surgery, 1998
- VASCULAR ENDOTHELIAL GROWTH FACTOR ENHANCES VASCULARIZATION IN MICROPOROUS SMALL-CALIBER POLYURETHANE GRAFTSASAIO Journal, 1997
- Phenotypic reversion of smooth muscle cells in hybrid vascular prosthesesCell Transplantation, 1995
- Self-organized, tubular hybrid vascular tissue composed of vascular cells and collagen for low-pressure-loaded venous systemCell Transplantation, 1995
- Surface microarchitectural design in biomedical applications: Preparation of microporous polymer surfaces by an excimer laser ablation techniqueJournal of Biomedical Materials Research, 1995
- Photochemical Protein Fixation on Polymer Surfaces via Derivatized Phenyl Azido GroupLangmuir, 1995
- The Effect of Porosity and Biomaterial on the Healing and Long-term Mechanical Properties of Vascular ProsthesesASAIO Journal, 1988
- Material test system for the evaluation of mechanical properties of biomaterialsJournal of Biomedical Materials Research, 1985