Lethal Malaria: Marchiafava and Bignami Were Right
Open Access
- 12 April 2013
- journal article
- review article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 208 (2), 192-198
- https://doi.org/10.1093/infdis/jit116
Abstract
One hundred and twenty years ago, the Italian malariologists Marchiafava and Bignami proposed that the fundamental pathological process underlying lethal falciparum malaria was microvascular obstruction. Since then, several alternative hypotheses have been proposed. These formed the basis for adjunctive interventions, which have either been ineffective or harmful. Recent evidence strongly suggests that Marchiafava and Bignami were right.Keywords
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