Silencing Dkk1 expression rescues dexamethasone-induced suppression of primary human osteoblast differentiation
Open Access
- 15 September 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Musculoskeletal Disorders
- Vol. 11 (1), 210
- https://doi.org/10.1186/1471-2474-11-210
Abstract
The Wnt/β-catenin pathway is a major signaling cascade in bone biology, playing a key role in bone development and remodeling. The objectives of this study were firstly, to determine the effects of dexamethasone exposure on Wnt/β-catenin signaling at an intracellular and transcriptional level, and secondly, to assess the phenotypic effects of silencing the Wnt antagonist, Dickkopf-1 (Dkk1) in the setting of dexamethasone exposure.Keywords
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