Antiproliferative effect of Baylis–Hillman adducts and a new phthalide derivative on human tumor cell lines
- 1 June 2006
- journal article
- Published by Elsevier BV in European Journal of Medicinal Chemistry
- Vol. 41 (6), 738-744
- https://doi.org/10.1016/j.ejmech.2006.03.006
Abstract
In this work we report our results concerning the study on the in vitro antiproliferative activity of 18 Baylis–Hillman adducts and some derivatives against a panel of humor tumor cell lines. A brief qualitative structure–activity relationship study indicated that carbon-carbon double bond and the presence of an electron-withdrawing substituent at the aromatic ring are essential for the activity. A quinoline–phthalide derivative has exhibited a potent effect on the proliferation of all cell lines. It is interesting to note their special cytotoxic activity against NCIADR cell line.Keywords
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