Speed congenics: a classic technique in the fast lane (relatively speaking)
- 31 October 1997
- journal article
- research article
- Published by Elsevier BV in Immunology Today
- Vol. 18 (10), 472-477
- https://doi.org/10.1016/s0167-5699(97)01126-2
Abstract
Marker-assisted selection protocol (MASP)-based strategies produce congenic strains with the target gene contained on clearly defined donor-derived genomic intervals in less than half the number of generations required by the classic protocol, Thus, the quality and speed of congenic strain construction are enhanced by this methodology. Here, Edward Wakeland and colleagues compare various MASP-based strategies and discuss their advantages with reference to immunological traits.Keywords
This publication has 16 references indexed in Scilit:
- Genetic Analysis of Autoimmune DiseaseCell, 1996
- Non-obese diabetic mice hemizygous at the T cell receptor α locus are susceptible to diabetes and sialitisEuropean Journal of Immunology, 1996
- A comprehensive genetic map of the mouse genomeNature, 1996
- Proportion of the Variation in Genetic Composition in Backcrossing Programs Explained by Genetic MarkersJournal of Heredity, 1996
- Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes.The Journal of Experimental Medicine, 1994
- Simulation of marker assisted selection for non-additive traitsGenetics Research, 1994
- Simulation of marker assisted selection in hybrid populationsGenetics Research, 1994
- Linkage on Chromosome 3 of Autoimmune Diabetes and Defective Fc Receptor for IgG in NOD miceScience, 1993
- Genetic analysis of autoimmune type 1 diabetes mellitus in miceNature, 1991
- Genetic control of diabetogenesis in NOD/Lt mice. Development and analysis of congenic stocksDiabetes, 1989