Diesel exhaust particulate (DEP) and nanoparticle exposures: What do DEP human clinical studies tell us about potential human health hazards of nanoparticles?
- 13 April 2010
- journal article
- research article
- Published by Informa UK Limited in Inhalation Toxicology
- Vol. 22 (8), 679-694
- https://doi.org/10.3109/08958371003758823
Abstract
Engineered nanoparticles (ENPs) are increasingly tested in cellular and laboratory-animal experiments for hazard potential, but there is a lack of health effects data for humans exposed to ENPs. However, human data for another source of nanoparticle (NP) exposure are available, notably for the NPs contained in diesel exhaust particulate (DEP). Studies of human volunteers exposed to diesel exhaust (DE) in research settings report DEP-NP number concentrations (i.e., >106 particles/cm3) that exceed number concentrations reported for worst-case exposure conditions for workers manufacturing and handling ENPs. Recent human DE exposure studies, using sensitive physiological instrumentation and well-characterized exposure concentrations and durations, suggest that elevated DE exposures from pre-2007 engines may trigger short-term changes in, for example, lung and systemic inflammation, thrombogenesis, vascular function, and brain activity. Considerable uncertainty remains both as to which DE constituents underlie the observed responses (i.e., DEP NPs, DEP mass, DE gases), and as to the implications of the observed short-term changes for the development of disease. Even so, these DE human clinical data do not give evidence of a unique toxicity for NPs as compared to other small particles. Of course, physicochemical properties of toxicological relevance may differ between DEP NPs and other NPs, yet overall, the DE human clinical data do not support the idea that elevated levels of NPs per se (at least in the DEP context) must be acutely toxic by virtue of their nano-sized nature alone.Keywords
This publication has 63 references indexed in Scilit:
- Experimental exposure to diesel exhaust increases arterial stiffness in manParticle and Fibre Toxicology, 2009
- Diesel Exhaust Inhalation Elicits Acute Vasoconstriction in VivoEnvironmental Health Perspectives, 2008
- Effects of diesel exhaust inhalation on heart rate variability in human volunteersEnvironmental Research, 2008
- Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epitheliumParticle and Fibre Toxicology, 2008
- Exposure to diesel exhaust induces changes in EEG in human volunteersParticle and Fibre Toxicology, 2008
- Comment on the Nanoparticle Conclusions in Crüts et al. (2008), "Exposure to diesel exhaust induces changes in EEG in human volunteers"Particle and Fibre Toxicology, 2008
- Thrombotic Markers in Metabolic Syndrome Subjects Exposed to Diesel ExhaustInhalation Toxicology, 2008
- Coagulation markers in healthy human subjects exposed to diesel exhaustThrombosis Research, 2007
- In Search of the Most Relevant Parameter for Quantifying Lung Inflammatory Response to Nanoparticle Exposure: Particle Number, Surface Area, or What?Environmental Health Perspectives, 2007
- Mass, surface area and number metrics in diesel occupational exposure assessmentJournal of Environmental Monitoring, 2005