Malignant Melanoma Arising From the Sphenoidal Sinus. Case Report.
Open Access
- 1 January 2000
- journal article
- case report
- Published by Japan Neurosurgical Society in Neurologia medico-chirurgica
- Vol. 40 (6), 329-334
- https://doi.org/10.2176/nmc.40.329
Abstract
Malignant melanomas arising from the sella turcica or sphenoidal sinus with bilateral invasion of the base of the skull or cavernous sinus are extremely rare. Whether the sella turcica or sphenoidal sinus is the site of origin is difficult to determine based on neuroradiological findings. An 83-year-old Japanese female presented with headache as the initial symptom. She suffered rapid progression of bilateral obstruction of the nasal cavity, left nasal bleeding, and bilateral visual field defects. The preoperative diagnosis was pituitary adenoma, metastatic tumor, or malignant paranasal tumor. Biopsy was performed. The histological diagnosis was malignant melanoma. Postoperatively, the tumor progressed rapidly. She suffered several cranial nerve pareses and hypopituitarism. She died within 6 months. Tumors arising from the sphenoidal sinus cause obstruction of the nasal cavity or nasal bleeding first, and then cause cranial nerve pareses by invasion of the cavernous sinus. This sequence of clinical manifestations can be attributed to the anatomical relationships between the sphenoidal sinus, nasal cavity, and cavernous sinus. Differential diagnosis of the origin in the sella turcica or sphenoidal sinus appears to be relatively easy based on further observation of the clinical course and symptoms.Keywords
This publication has 15 references indexed in Scilit:
- Sinonasal Melanoma: A Clinicopathologic Study of 25 Cases and Literature Meta-analysisJAMA Otolaryngology–Head & Neck Surgery, 1997
- Primary sellar haemorragic melanoma: case report and review of the literatureBritish Journal of Neurosurgery, 1997
- Primary Intracranial MelanomaNeurologia medico-chirurgica, 1990
- Choroidal melanomas: correlation of NMR spectroscopy and MR imaging.Radiology, 1986
- Cranial computed tomography of malignant melanomaAmerican Journal of Roentgenology, 1981
- Primary Intracranial Melanoma Presenting as a Suprasellar TumorNeurosurgery, 1980
- Neurovascular relationships of the sphenoid sinusJournal of Neurosurgery, 1979
- Melanoma of the pituitaryJournal of Neurosurgery, 1976
- MUCOSAL MELANOMAS OF THE HEAD AND NECKAmerican Journal of Roentgenology, 1967
- Hypopituitarism caused by a melanoma of the pituitary glandJournal of Clinical Pathology, 1963