Predictive Factors for Intracerebral Hemorrhage in Patients with Cavernous Angiomas
- 1 April 2005
- journal article
- research article
- Published by Taylor & Francis Ltd in Neurological Research
- Vol. 27 (3), 314-318
- https://doi.org/10.1179/016164105x39914
Abstract
Prediction of intracerebral hemorrhage (ICH) in patients with cavernous angiomas is not totally elucidated. The aims of our study were to determine the rate of cerebral hemorrhage, its associated factors, and the clinical outcome in patients with cavernous angiomas in a Hispanic population.We studied 133 patients with cavernous angiomas. The patients were classified into two groups depending on whether they presented an ICH. A comparative analysis of demographics and clinical data, neuroimaging characteristics, and prognosis was carried out in patients with and without hemorrhage. The hemorrhage rate (expressed as the percentage per patient per year) was also estimated.Seventy-eight patients (59%) had hemorrhage. Non-lobar location of angiomas was associated with hemorrhage [OR 4.82 (CI 95% 2.17-10.73; p=<0.001)]. In contrast, factors associated with a decreased risk of hemorrhage were a family history of epilepsy [OR 0.30 (CI 95% 0.10-0.79; p=0.016)] and lobar location of the angiomas [OR 0.21 (CI 95% 0.09-0.46; p=<0.001)]. The hemorrhagic rate of 1.71% per patient per year was influenced by the location. It was only 1.22% per patient per year in lobar angiomas and 2.33, 2.39, and 2.82% per patient per year for brainstem, cerebellum, and deep hemispheric angiomas, respectively.The non-lobar location of cavernous angiomas gives a higher risk of hemorrhage in our Mexican mestizo population, without the hemorrhage being related to either age or sex.Keywords
This publication has 29 references indexed in Scilit:
- Growth, Subsequent Bleeding, and De Novo Appearance of Cerebral Cavernous AngiomasNeurosurgery, 1996
- Natural history of intracranial cavernous malformationsJournal of Neurosurgery, 1995
- Angiographically Occult Vascular MalformationsNeurosurgery, 1994
- Mixed Vascular Malformations of the BrainNeurosurgery, 1993
- Surgical resection of intramedullary spinal cord cavernous malformationsJournal of Neurosurgery, 1993
- Intramedullary Cavernous Angiomas of the Spinal CordNeurosurgery, 1992
- Cavernous Malformations of the Spinal CordNeurosurgery, 1988
- Cerebral Cavernous MalformationsThe New England Journal of Medicine, 1988
- Cavernous angiomas of the spinal cordJournal of Neurosurgery, 1988
- Prognosis of Patients with Severe Head InjuryNeurosurgery, 1979