The Roles of IL-6, IL-10, and IL-1RA in Obesity and Insulin Resistance in African-Americans
Open Access
- 1 December 2011
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 96 (12), E2018-E2022
- https://doi.org/10.1210/jc.2011-1497
Abstract
Objective: The aim of the study was to investigate the associations between IL-1 receptor antagonist (IL-1RA), IL-6, IL-10, measures of obesity, and insulin resistance in African-Americans. Research Design and Methods: Nondiabetic participants (n = 1025) of the Howard University Family Study were investigated for associations between serum IL (IL-1RA, IL-6, IL-10), measures of obesity, and insulin resistance, with adjustment for age and sex. Measures of obesity included body mass index, waist circumference, hip circumference, waist-to-hip ratio, and percent fat mass. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR). Data were analyzed with R statistical software using linear regression and likelihood ratio tests. Results: IL-1RA and IL-6 were associated with measures of obesity and insulin resistance, explaining 4–12.7% of the variance observed (P values < 0.001). IL-1RA was bimodally distributed and therefore was analyzed based on grouping those with low vs. high IL-1RA levels. High IL-1RA explained up to 20 and 12% of the variance in measures of obesity and HOMA-IR, respectively. Among the IL, only high IL-1RA improved the fit of models regressing HOMA-IR on measures of obesity. In contrast, all measures of obesity improved the fit of models regressing HOMA-IR on IL. IL-10 was not associated with obesity measures or HOMA-IR. Conclusions: High IL-1RA levels and obesity measures are associated with HOMA-IR in this population-based sample of African-Americans. The results suggest that obesity and increased levels of IL-1RA both contribute to the development of insulin resistance.Keywords
This publication has 17 references indexed in Scilit:
- Insulin Resistance Predicts Mortality in Nondiabetic Individuals in the U.S.Diabetes Care, 2010
- Relationships Among Obesity, Inflammation, and Insulin Resistance in African Americans and West AfricansObesity, 2010
- Recommended community strategies and measurements to prevent obesity in the United States.2009
- Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 DiabetesDiabetes Care, 2009
- Adipose tissue: a regulator of inflammationBest Practice & Research Clinical Endocrinology & Metabolism, 2005
- Association of Interleukin-6, C-reactive Protein, Interleukin-10 and Adiponectin Plasma Concentrations with Measures of Obesity, Insulin Sensitivity and Glucose MetabolismExperimental and Clinical Endocrinology & Diabetes, 2005
- Adipose tissue is a regulated source of interleukin-10Cytokine, 2005
- Interleukin-6 (IL-6) Induces Insulin Resistance in 3T3-L1 Adipocytes and Is, Like IL-8 and Tumor Necrosis Factor-α, Overexpressed in Human Fat Cells from Insulin-resistant SubjectsOnline Journal of Public Health Informatics, 2003
- Raised Interleukin‐6 Levels in Obese PatientsObesity Research, 2000
- Involvement of interleukin 1 and interleukin 1 antagonist in pancreatic β-cell destruction in insulin-dependent diabetes mellitusCytokine, 1993