The excretion of [14C] butylated hydroxytoluene in the rat
- 1 June 1967
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 19 (6), 383-387
- https://doi.org/10.1111/j.2042-7158.1967.tb09564.x
Abstract
The excretion of small doses of [14C]labelled butylated hydroxytoluene has been examined in the rat. Parenteral doses are excreted slowly in urine and faeces over 4 days. Biliary excretion is rapid. The biliary radioactivity is absorbed readily from the gut and a rapid enterohepatic cycle has been found to operate over at least 96 hr.Keywords
This publication has 9 references indexed in Scilit:
- The biliary metabolites of butylated hydroxytoluene in the ratJournal of Pharmacy and Pharmacology, 1967
- Summary of toxicological dataFood and Cosmetics Toxicology, 1965
- The absorption and excretion of butylated hydroxytoluene (BHT) in the ratFood and Cosmetics Toxicology, 1965
- THE INFLUENCE OF ENTEROHEPATIC CIRCULATION ON TOXICITY OF DRUGS*Annals of the New York Academy of Sciences, 1965
- The Urinary Excretion of 14C-Labelled Butylated Hydroxytoluene by the RatJournal of Pharmacy and Pharmacology, 1963
- The Urinary Excretion of Trittated Butylated Hydroxyanisole and Butylated Hydroxytoluene in the RatJournal of Pharmacy and Pharmacology, 1962
- Studies on Food Additives. VIII. Metabolism of α-Hydroxy-2, 6-di-tert-butyl-p-cresol. Isolation of Metabolites.CHEMICAL & PHARMACEUTICAL BULLETIN, 1962
- Biopharmaceutics: Absorption AspectsJournal of Pharmaceutical Sciences, 1961
- The metabolism of 3:5-di-tert.-butyl-4-hydroxytoluene and 3:5-di-tert.-butyl-4-hydroxybenzoic acid in the rabbitBiochemical Journal, 1961