A cross sectional study to compare cardiac structure and diastolic function in adolescents and young adults with youth-onset type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Study
Open Access
- 7 July 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Cardiovascular Diabetology
- Vol. 20 (1), 1-10
- https://doi.org/10.1186/s12933-021-01328-0
Abstract
To compare left ventricular structure (LV) and diastolic function in young adults with youth- onset diabetes by type, determine the prevalence of abnormal diastolic function by diabetes type using published values from age similar healthy controls, and examine the risk factors associated with diastolic function. In a cross sectional analysis we compared LV structure and diastolic function from two dimensional echocardiogram in participants with type 1 (T1D) and type 2 diabetes (T2D) who participated in the SEARCH for Diabetes in Youth Study. Linear models were used to examine the risk factors associated with worse diastolic function. Of 479 participants studied, 258 had T1D (mean age 21.2 ± 5.2 years, 60.5% non-Hispanic white, 53.9% female) and 221 had T2D (mean age 24.8 ± 4.3 years, 24.4% non-Hispanic white, 73.8% female). Median diabetes duration was 11.6 years. Participants with T2D had greater LV mass index and worse diastolic function that persisted after adjustment for differences in risk factors compared with participants with T1D (all p < 0.05). Abnormal diastolic function, quantified using healthy controls, was pronounced in both groups but greater in those with T2D than T1D (T2D: 57.7% vs T1D: 47.2%, respectively), p < 0.05. Risk factors associated with worse diastolic function included older age at diabetes diagnosis, female sex, higher BP, heart rate and HbA1c and longer diabetes duration. LV structure and diastolic function is worse in individuals with T2D compared to T1D. However, abnormal diastolic function in seen in both groups compared to published values from age similar healthy controls.Keywords
Funding Information
- National Institute of Diabetes and Digestive and Kidney Diseases
- Centers for Disease Control and Prevention
This publication has 42 references indexed in Scilit:
- Cardiac Geometry and Function in Diabetic or Prediabetic Adolescents and Young AdultsDiabetes Care, 2011
- Etiological Approach to Characterization of Diabetes TypeDiabetes Care, 2011
- Prediction of All-Cause Mortality From Global Longitudinal Speckle StrainCirculation: Cardiovascular Imaging, 2009
- Structural and Functional Cardiac Abnormalities in Adolescent Girls with Poorly Controlled Type 2 DiabetesDiabetes Care, 2009
- Impact of diabetes on outcomes in patients with low and preserved ejection fraction heart failure: An analysis of the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) programmeEuropean Heart Journal, 2008
- Evaluation of Concentric Left Ventricular Geometry in HumansHypertension, 2005
- Indexing left ventricular mass to account for differences in body size in children and adolescents without cardiovascular diseaseThe American Journal of Cardiology, 1995
- Effect of growth on variability of left ventricular mass: Assessment of allometric signals in adults and children and their capacity to predict cardiovascular riskJournal of the American College of Cardiology, 1995
- Prognosis of left ventricular geometric patterns in the Framingham heart studyJournal of the American College of Cardiology, 1995
- Diabetes and cardiovascular disease. The Framingham studyJAMA, 1979