Opposite Role of Pro‐Inflammatory Alleles in Acute Myocardial Infarction and Longevity
- 10 May 2006
- journal article
- research article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 1067 (1), 270-275
- https://doi.org/10.1196/annals.1354.035
Abstract
The major trait characterizing offspring in centenarians is a reduction in the prevalence of cardiovascular disease. Because a pro‐inflammatory genotype seems to contribute significantly to the risk of coronary heart disease, alleles associated with disease susceptibility would not be included in the genetic background favoring longevity, as suggested by our previous studies on inflammatory cytokines. To confirm whether genotypes of inflammatory molecules play an opposite role in atherosclerosis and longevity, we are studying the role of other proinflammatory alleles, such as pyrin and CCR5, in acute myocardial infarction and longevity. The results support the hypothesis that the genetic background favoring cardiovascular diseases is detrimental to longevity. In addition, they suggest that the centenarian genetic background may be useful for investigating genetic key components of age‐associated diseases that are characterized by a multifactorial etiology.Keywords
This publication has 13 references indexed in Scilit:
- Inflammation, Longevity, and Cardiovascular DiseasesAnnals of the New York Academy of Sciences, 2006
- Inflammation and Life-SpanScience, 2005
- Role of Toll-like Receptor 4 in Acute Myocardial Infarction and LongevityPublished by American Medical Association (AMA) ,2004
- Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenariansMechanisms of Ageing and Development, 2004
- Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart diseaseJournal of Medical Genetics, 2004
- CD14 and toll-like receptor 4: a link between infection and acute coronary events?Heart, 2004
- Cardiovascular Advantages Among the Offspring of CentenariansThe Journals of Gerontology: Series A, 2003
- Inflammation and AtherosclerosisCirculation, 2002
- Genetic variation at the chemokine receptors CCR5/CCR2 in myocardial infarctionGenes & Immunity, 2001
- Genetic Susceptibility to Death from Coronary Heart Disease in a Study of TwinsNew England Journal of Medicine, 1994