T-cell selection
- 1 April 1998
- journal article
- review article
- Published by Elsevier BV in Current Opinion in Immunology
- Vol. 10 (2), 214-219
- https://doi.org/10.1016/s0952-7915(98)80251-3
Abstract
Major histocompatibility complex (MHC) molecules in the thymus select from the repertoire of germline receptors those that will be most useful in mounting responses to antigen in the periphery. Recent data has shed light on the involvement of self peptides presented by the MHC in this process, and has indicated that a requirement for the constant recognition of ‘self’ may be essential for T-cell longevity in the periphery.Keywords
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