Clinical aspects of inflammatory bowel disease
Open Access
- 11 August 2009
- journal article
- viewpoints on-animal-models-of-human-disease
- Published by Wiley in European Journal of Immunology
- Vol. 39 (8), 2026-2030
- https://doi.org/10.1002/eji.200939601
Abstract
Inflammatory bowel disease (IBD) accompanies its patients throughout life. Current treatment options do not lead to a cure and are accompanied by significant toxicities. Numerous animal models contributed to the understanding of the pathogenesis of the disease and led to the development of novel treatment strategies. Genome-wide association analysis added a novel dimension. Here, we discuss how characterization of mutated genes in animal models supports the identification of future therapeutic targets.Keywords
Funding Information
- DFG (SFB 633, Si 749/5-1)
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