A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
- 7 August 1997
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 388 (6642), 548-554
- https://doi.org/10.1038/41493
Abstract
Nuclear transcription factors of the NF-κB/Rel family are inhibited by IκB proteins, which inactivate NF-κB by trapping it in the cell cytoplasm. Phosphorylation of IκBs marks them out for destruction, thereby relieving their inhibitory effect on NF-κB. A cytokine-activated protein kinase complex, IKK (for IκB kinase), has now been purified that phosphorylates IκBs on the sites that trigger their degradation. A component of IKK was molecularly cloned and identified as a serine kinase. IKK turns out to be the long-sought-after protein kinase that mediates the critical regulatory step in NF-κB activation.Keywords
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