Histones and Their Modification
- 1 January 1986
- journal article
- research article
- Published by Taylor & Francis Ltd in Critical Reviews in Biochemistry
- Vol. 20 (2), 201-263
- https://doi.org/10.3109/10409238609083735
Abstract
Histones constitute the protein core around which DNA is coiled to form the basic structural unit of the chromosome known as the nucleosome. Because of the large amount of new histone needed during chromosome replication, the synthesis of histone and DNA is regulated in a complex manner. During RNA transcription and DNA replication, the basic nucleosomal structure as well as interactions between nucleosomes must be greatly altered to allow access to the appropriate enzymes and factors. The presence of extensive and varied post-translational modifications to the otherwise highly conserved histone primary sequences provides obvious opportunities for such structural alterations, but despite concentrated and sustained effort, causal connections between histone modifications and nucleosomal functions are not yet elucidated.Keywords
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