MC3T3-E1 cell differentiation and in vivo bone formation induced by phosphoserine
- 23 February 2011
- journal article
- Published by Springer Science and Business Media LLC in Biotechnology Letters
- Vol. 33 (7), 1473-1480
- https://doi.org/10.1007/s10529-011-0565-0
Abstract
Bone formation induced by phosphoserine was investigated in vitro and in vivo using MC3T3-E1 cells and a rabbit calvarial osseous defect model. MC3T3-E1 cells supplemented by phosphoserine displayed two-fold higher alkaline phosphatase activity and mineralization nodule formation, and calvarial defects treated with phosphoserine showed statistically significant new bone formation compared with the control (P < 0.05).Keywords
This publication has 21 references indexed in Scilit:
- Fabrication and cellular biocompatibility of porous carbonated biphasic calcium phosphate ceramics with a nanostructureActa Biomaterialia, 2009
- Three-Dimensional Technology and Bone Morphogenetic Protein in Frontal Bone ReconstructionThe Journal of Craniofacial Surgery, 2006
- Treatment with amino acids in serine deficiency disordersJournal of Inherited Metabolic Disease, 2005
- Effects of bone morphogenetic protein‐2 and hyaluronic acid on the osseointegration of hydroxyapatite‐coated implants: An experimental study in sheepJournal of Biomedical Materials Research Part A, 2005
- Inorganic phosphate regulates multiple genes during osteoblast differentiation, including Nrf2Experimental Cell Research, 2003
- Structure–function relationship in serine hydroxymethyltransferaseBiochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003
- Influence of osteocalcin and collagen I on the mechanical and biological properties of Biocement DBiomolecular Engineering, 2002
- The role of surface functional groups in calcium phosphate nucleation on titanium foil: a self-assembled monolayer techniqueBiomaterials, 2002
- Enhancement of bone ingrowth in a titanium fiber mesh implant by rhBMP-2 and hyaluronic acidJournal of Materials Science: Materials in Medicine, 2001
- Bone SialoproteinCritical Reviews in Oral Biology & Medicine, 1999